Method for derivitization of polynucleotides

Details Method for derivitization of polynucleotides Method for derivitization of polynucleotides

C - Chemistry, Metallurgy

07

H

195/1.13

C07H 1/02 (2006.01) C07H 1/06 (2006.01) C07H 21/00 (2006.01)

Patent

CA 1301673

- 19 - ABSTRACT A method for the preparation of a 3' end functionalized polynucleotide is disclosed. An amine- functionalized solid phase support is treated sequentially with an anhydride, then with an 1- hydroxylamine. A polynucleotide is chemically synthesized on the treated support and is subsequently cleaved therefrom by hydrolysis of the amide bonds. A polynucleotide having a 3' free primary amine is recovered for use in hybridization assays and other uses.

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