Method for detecting a protein of the tubulin...

G - Physics – 01 – N

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G01N 33/574 (2006.01)

Patent

CA 2299168

The invention concerns a method for detection and/or prognosis of cancer by detecting a protein of the tubulin tyrosination-detyrosination cycle (absence of tubulin-tyrosin-ligase (TTL) and/or presence of tubulin .DELTA.2) and a detection and/or prognosis kit (metastatic potentiality, invasive character, rate of tumour development) of a cancer. Said method consists in detecting, in a tissue sample or in a biological fluid, a protein of the tubulin tyrosination-detyrosination cycle, selected in the group consisting of tubulin-tyrosin-ligase and tubulin .DELTA.2 and/or an antibody directed against one of these proteins.

Procédé de dépistage et/ou de pronostic d'un cancer par détection d'une protéine du cycle de tyrosination-détyrosination de la tubuline (absence de tubuline-tyrosine-ligase (TTL) et/ou présence de tubuline .DELTA.2) ainsi que kit de dépistage et/ou de pronostic (potentialité métastatique, caractère invasif, vitesse de développement de la tumeur) d'un cancer. Ledit procédé comprend la détection, dans un échantillon tissulaire ou dans un fluide biologique, d'une protéine du cycle de tyrosination-détyrosination de la tubuline, sélectionnée dans le groupe constitué par la tubuline-tyrosine- ligase et la tubuline .DELTA.2 et/ou d'un anticorps dirigé contre l'une de ces protéines.

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