Method for detecting and modifying mismatches and mutations...

G - Physics – 01 – N

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

G01N 33/53 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2369470

An objective of this invention is to provide a method for effectively detecting mismatches or mutations in a nucleic acid using MutM protein and a method for effectively separating a nucleic acid with mismatches using MutM protein. MutM protein has been found to be able to recognize any mismatches involving cytosine in a nucleic acid. It has also been found that, using the characteristic of the MutM protein, mismatches in a double-stranded nucleic acid can be efficiently detected and a double-stranded nucleic acid with mismatches can be separated from double-stranded nucleic acid samples.

La présente invention concerne une technique permettant de détecter efficacement des mésappariements ou des mutations dans l'acide nucléique par l'utilisation de la protéine MutM, et une technique permettant d'isoler efficacement les mésappariements d'un acide nucléique par l'utilisation de la protéine MutM. On a découvert que la protéine MutM était capable de reconnaître tous les mésappariements dans lesquels la cytosine était concernée qui surviennent dans un acide nucléique. On a également découvert qu'en utilisant les caractéristiques de la protéine MutM, on pouvait efficacement détecter des mésappariements dans un acide nucléique à double brin, et que l'on pouvait isoler un acide nucléique à double brin présentant des mésappariements, parmi des échantillons d'acides nucléiques à double brin.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Method for detecting and modifying mismatches and mutations... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for detecting and modifying mismatches and mutations..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for detecting and modifying mismatches and mutations... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1656914

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.