C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) C12N 5/0783 (2010.01) C07K 14/74 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2350185
The invention concerns multimers developed from recombinant proteins analogues of MHC class I, characterised in that the proteins comprise at least an alteration in the zone of interaction of a heavy chain with the T-cell co-receptor CD8 leading to a reduction, even the suppression of the affinity of the interaction between the heavy chain and CD8. Said multimers forming complexes with antigenic peptides are useful for diagnostic and therapeutic purposes.
L'invention vise des multimères élaborés à partir de protéines recombinantes analogues de CMH de classe I, caractérisés en ce que les protéines comportent au moins une altération dans la zone d'interaction d'une chaîne lourde avec le co-récepteur CD8 des lymphocytes T conduisant à une réduction, voire à la suppression de l'affinité de l'interaction entre la chaîne lourde et le CD8. Applications de ces multimères complexés à des peptides antigéniques à des fins diagnostiques et thérapeutiques.
Bodinier Marie
Bonneville Marc
Davodeau Francois
Lang Francois
Institut National de La Sante Et de La Recherche Medicale (inser
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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