Method for detecting and removing endotoxin

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/33 (2006.01) C07K 1/22 (2006.01) C07K 14/005 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2595476

The invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. The invention also relates to methods for depleting endotoxins from solutions and samples using the inventive bacteriophage tail proteins and to a detection method for endotoxins.

L'invention concerne des protéines de queue de bactériophage et leurs dérivés et fragments qui peuvent se lier à des endotoxines en l'absence d'ions positifs bivalents, notamment Ca2+ ou Mg2+. L'invention concerne également des procédés pour appauvrir des solutions et échantillons en endotoxines au moyen des protéines de queue de bactériophage selon l'invention, ainsi qu'un procédé de détection pour des endotoxines.

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