Method for detecting cancer

G - Physics – 01 – N

Patent

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Details

G01N 33/574 (2006.01) C12N 15/09 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2732980

The present invention relates to a method for detecting cancer, comprising measuring the expression of a polypeptide having a reactivity of binding to an antibody against a CAPRIN-1 protein having an amino acid sequence shown in any one of the even-numbered SEQ ID NOS: 2-30 in the Sequence Listing via an antigen-antibody reaction in a sample separated from a living organism, and, a reagent for detecting a cancer comprising the CAPRIN-1 protein or a fragment thereof, an antibody against the CAPRIN-1 protein or a fragment thereof, or a polynucleotide encoding the CAPRIN-1 protein or a fragment thereof.

La présente invention concerne un procédé de détection du cancer comprenant la mesure de lexpression dun polypeptide dans un échantillon séparé dun organisme vivant, le polypeptide ayant une réactivité pour se lier, par une réaction antigène-anticorps, à un anticorps dirigé contre la protéine CAPRINE 1 comprenant une séquence dacides aminés décrite dans une séquence de numéro pair choisie parmi SEQ ID N° 2 à SEQ ID N° 30 décrites dans la Liste des séquences. La présente invention concerne en outre un réactif de détection du cancer comprenant la protéine CAPRINE 1 ou un fragment de celle-ci, un anticorps dirigé contre la protéine CAPRINE 1 ou le fragment de celle-ci, ou un polynucléotide codant pour la protéine CAPRINE 1 ou le fragment de celle-ci.

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