Method for detecting misfolded proteins and prions

Details Method for detecting misfolded proteins and prions Method for detecting misfolded proteins and prions

G - Physics

01

N

G01N 33/53 (2006.01) B01L 3/00 (2006.01) C07K 17/00 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2597912

The invention provides methods and kits for detecting conformationally altered proteins, such as prions or other proteins associated with disease states, in a sample. The methods comprise selectively capturing and separating complexes of peptide and conformationally altered protein from substances that interfere with detection of such complexes, and preferably amplification of the detection signal b addition of a second double-labeled peptide.

La présente invention a trait à des procédés et des trousses pour la détection de protéines à altération conformationnelle, tels que des prions et autres protéines associés à des états morbides, dans un échantillon. Les procédés comprennent la capture sélective et la séparation de complexes de peptide et de protéine à altération conformationnelle à partir de substances qui entravent la détection de tels complexes, et de préférence l'amplification de la détection de signal par l'ajout d'un deuxième peptide à double marqueur.

Affiliated with

Also associated with

Rating

Method for detecting misfolded proteins and prions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for detecting misfolded proteins and prions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for detecting misfolded proteins and prions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1890998