Method for detecting pathogenic prion proteins by means of...

Details Method for detecting pathogenic prion proteins by means of... Method for detecting pathogenic prion proteins by means of...

G - Physics

01

N

G01N 33/569 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2416450

A method for detecting pathogenic prion proteins in a sample which is of a body fluid of human or animal origin and contains a PrP protein which assumes a first, natural, nonpathological conformation, PrP c, and a second, pathological conformation, termed PrP Sc, is described, in which, - in a sample of a body fluid, which can also be chemically modified, - the prion proteins are reacted with a chemical agent, with the formation of covalent bonds, and - the prion proteins which are thereby chemically modified are analyzed mass-spectroscopically, with at least one further peak being observed in the mass spectrum when pathogenic prions are present.

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