Method for detection of condition in consciousness disorder...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/37 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2642546

Disclosed is a method for detection of a condition in a consciousness disorder patient. The method comprises analyzing the amount and/or activity of a von Willebrand factor-cleaving enzyme in the patient. Also disclosed is a kit for detecting a condition in a consciousness disorder patient. The kit comprises an antibody capable of binding specifically to a von Willebrand factor-cleaving enzyme or a fragment of the antibody, or von Willebrand factor or a fragment thereof. Examples of the detection of cerebral vascular disorder, the detection of a condition include the detection of arteriosclerotic angiopathy or the detection or prediction of the degree of severity.

La présente invention concerne un procédé pour la détection d'une condition chez un patient souffrant d'un trouble de la conscience. Le procédé comprend l'analyse de la quantité et/ou de l'activité d'une enzyme de clivage du facteur de von Willebrand chez le patient. L'invention concerne également une trousse pour détecter une condition chez un patient souffrant d'un trouble de la conscience. La trousse comprend un anticorps pouvant se lier spécifiquement à une enzyme de clivage d'un facteur de von Willebrand ou un fragment de l'anticorps, ou un facteur de von Willebrand ou un fragment de celui-ci. Des exemples de la détection d'un trouble vasculaire cérébral, de la détection d'une condition, comprennent la détection d'une angiopathie artérioscléreuse ou la détection ou la prédiction du degré de gravité.

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