Method for detection of mutations

Details Method for detection of mutations Method for detection of mutations

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2113716

2113716 9302216 PCTABS00019 A method for detecting mutations, such as a single base change or an addition or deletion of about one to four base pairs, is based on the use of a DNA mismatch-binding protein, such as MutS, which binds to a nucleic acid hybrid having a single base mismatch or unpaired base or bases, thereby allowing the detection of mutations involving as little as one base change in a nucleotide sequence. Such a method is useful for diagnosing a variety of important disease states or susceptibilities, for example, detecting the presence of a mutated oncogen. The method shares the efficiency advantages of PCR-based methods but is much simpler and cheaper to perform. Also provided is a kit useful for practicing the method of the present invention.

Affiliated with

Also associated with

Rating

Method for detection of mutations does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for detection of mutations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for detection of mutations will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1519237