Method for detection or treatment of graft versus host disease

Details Method for detection or treatment of graft versus host disease Method for detection or treatment of graft versus host disease

G - Physics

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G01N 33/53 (2006.01) A61K 39/395 (2006.01) A61P 37/06 (2006.01) G01N 27/62 (2006.01) G01N 30/72 (2006.01) G01N 30/88 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2692332

Disclosed is a method for detecting a graft versus host disease, which is characterized by measuring the quantity of CCL8 protein in a sample collected from a subject and utilizing the measurement value as a measure of the diagnosis or course of the graft versus host disease. Also disclosed is a diagnostic agent for a graft versus host disease, which comprises an anti--CCL8 antibody. The method enables the diagnosis of the occurrence of a graft versus host disease or the monitoring of the course of a graft versus host disease, particularly the differential diagnosis between a graft versus host disease and an infectious disease. Further disclosed is a therapeutic method for a graft versus host disease by using an anti-CCL8 antibody.

La présente invention concerne un procédé de détection de la maladie du greffon contre l'hôte, caractérisé par la mesure de la quantité de protéine CCL8 présente dans un échantillon recueilli auprès d'un sujet et par le recours à la valeur mesurée pour poser le diagnostic de la maladie du greffon contre l'hôte ou pour en évaluer l'évolution. La présente invention concerne également un agent de diagnostic de la maladie du greffon contre l'hôte comprenant un anticorps anti-CCL8. Ce procédé permet le diagnostic de la survenue de la maladie du greffon contre l'hôte ou le suivi de l'évolution de la maladie du greffon contre l'hôte. Il permet, en particulier, de bien faire la différence, en termes de diagnostic, entre la maladie du greffon contre l'hôte et une maladie infectieuse. L'invention concerne de plus un procédé thérapeutique applicable à la maladie du greffon contre l'hôte et utilisant un anticorps anti-CCL8.

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