C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/37 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2641189
Disclosed is a method for determination of a condition of disseminated intravascular coagulation syndrome (DIC) in a DIC patient, wherein the method comprises determining the amount and/or the enzymatic activity of a von Willebrand factor (vWF)-cleaving enzyme (ADAMTS13) (preferably also the amount of vWF). Also disclosed is a kit for determination of a condition of DIC, wherein the kit comprises an antibody capable of binding specifically to ADAMTS13 or a fragment thereof. The method enables to achieve a differential diagnosis of a thrombotic thrombocytopenic purpura (TTP) patient from a DIC patient, which has been difficult to achieve previously only based on clinical observations or only by using conventional markers.
L'invention concerne un procédé permettant de déterminer l'état d'un syndrome de coagulation intravasculaire disséminée (CIVD) chez un patient atteint de CIVD. Le procédé consiste à déterminer la quantité et/ou l'activité enzymatique de l'enzyme de clivage du facteur de von Willebrand (vWF) (ADAMTS13) (de préférence aussi la quantité de vWF). L'invention concerne également une trousse permettant de déterminer l'état d'une CIVD, qui comprend un anticorps pouvant se lier spécifiquement à ADAMTS13 ou à un fragment de celle-ci. Le procédé permet d'obtenir un diagnostic différentiel entre un patient atteint de purpura thrombotique thrombopénique et un patient atteint de CIVD, ce qui auparavant était difficile à obtenir sur la seule base des observations cliniques ou au moyen de marqueurs classiques seulement.
Furusaki Fumio
Igami Ko
Ono Tomoko
Watanabe Shinichiro
Fetherstonhaugh & Co.
Juridical Foundation The Chemo-Sero-Therapeutic Research Institu
Mitsubishi Chemical Medience Corporation
Mitsubishi Kagaku Iatron Inc.
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