Method for determination of effective dose of methotrexate

Details Method for determination of effective dose of methotrexate Method for determination of effective dose of methotrexate

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2619615

[PROBLEMS] To provide a test method for determination of the effective dose of methotrexate in each patient and a method for treatment of rheumatoid arthritis. [MEANS FOR SOLVING PROBLEMS] Disclosed is a method for determination of the A1298C polymorphism in MTHFR gene in a patient suffering from rheumatoid arthritis. The method can be used for the determination of the effective dose of methotrexate in each patient. Also disclosed is a method for treatment of rheumatoid arthritis in each patient.

L~invention concerne une méthode de test pour déterminer la dose efficace de méthotrexate pour chaque patient et une méthode de traitement de la polyarthrite rhumatoïde. Elle concerne une méthode pour déterminer le polymorphisme de A1298C dans un gène MTHFR pour un patient souffrant de polyarthrite rhumatoïde. La méthode peut être utilisée pour déterminer la dose efficace de méthotrexate chez chaque patient. L~invention concerne aussi une méthode pour traiter la polyarthrite rhumatoïde chez chaque patient.

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