A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61P 31/00 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2578189
There is disclosed a method for determining an administration regimen for an oral killed vaccine for use in immunising individuals in a population against an infection or disease. The method comprise administering the oral killed vaccine to one or more individuals in a population and identifying an indicative dosaging level of the vaccine which induces a reduction in immune system responsiveness to the vaccine in the one or more individuals. A further dosaging level that elicits an immune response in one or more individuals of the population without inducing the reduction in immune system responsiveness to the vaccine is then determined.
L'invention concerne une méthode de détermination d'un schéma posologique d'administration d'un vaccin inactivé oral utilisé lors de l'immunisation d'individus d'une population, dans la lutte contre une infection ou une maladie. Cette méthode consiste à administrer le vaccin inactivé oral à au moins un individu d'une population et à identifier un niveau de dosage indicatif du vaccin qui permet d'induire une diminution de la sensibilité du système immunitaire vis-à-vis du vaccin chez l'individu. Puis, est déterminé un autre niveau de dosage permettant d'éliciter une réponse immunitaire chez l'individu de la population sans induire une diminution de la sensibilité du système immunitaire vis-à-vis du vaccin.
Clancy Robert
Comans Phillip
Pang Gerald
Gowling Lafleur Henderson Llp
Hunter Immunology Limited
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