Method for determining efficacy of reverse cholesterol...

Details Method for determining efficacy of reverse cholesterol... Method for determining efficacy of reverse cholesterol...

A - Human Necessities

61

K

A61K 35/60 (2006.01) A61K 31/44 (2006.01) A61K 38/17 (2006.01) A61K 38/44 (2006.01) G01N 33/50 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2438899

This invention provides a method for screening and/or determining the efficacy of known or potential reverse cholesterol transport-enhancing compounds in mammals that avoids the need for measuring cellular protein or mRNA levels and instead employs measurements of CD14 levels in blood.

L'invention concerne un procédé de criblage et/ou de détermination de l'efficacité de composés connus ou potentiels de stimulation du transport inverse du cholestérol chez les mammifères. Ce procédé s'affranchit de la mesure des taux d'ARNm ou des protéines cellulaires et se base plutôt sur les mesures des taux de CD14 dans le sang.

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