Method for determining immune system affecting compounds

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 16/00 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) C07K 14/52 (2006.01) C07K 14/735 (2006.01) C07K 14/75 (2006.01) C07K 14/765 (2006.01) C07K 14/78 (2006.01)

Patent

CA 2526950

The present invention relates to a method for increasing efficacy and/or possibility of therapeutic treatment of cancer, wherein any dys-regulatory mechanism, including inducing factor/s, of the production of immunoregulatory substances, including one or more cytokines, including IL-1.beta., IL-1Ra, IL- 6, IL-10, IL-17, TNF-.alpha., and others, is therapeutically controlled to minimise pathological production of such immunoregulatory substances, to enhance the therapeutic control of a malignant tumour in a subject suffering from a cancer, a method for analysing dys-regulatory mechanism controlling substances, kit for such analysis, use of certain compounds for preparing pharmaceutical preparations, and pharmaceutical preparations.

La présente invention se rapporte à un procédé d'accroissement de l'efficacité et/ou de la possibilité de traitement thérapeutique du cancer. Selon ce procédé, tout mécanisme dys-régulateur, tel qu'un ou plusieurs facteurs d'induction de la production de substances immuno-régulatrices, telles qu'une ou plusieurs cytokines, telles que IL-1.beta., IL-1Ra, IL-6, IL-10, IL-17, TNF-.alpha., et analogues, est régulé de manière thérapeutique afin de minimiser la production pathologique de telles substances immuno-régulatrices, dans le but d'accroître la régulation thérapeutique d'une tumeur maligne chez un sujet souffrant d'un cancer. L'invention se rapporte également à un procédé d'analyse des substances de régulation des mécanismes dys-régulateurs, à une trousse permettant la mise en oeuvre de cette analyse, à l'utilisation de certains composés pour la production de préparations pharmaceutiques, ainsi qu'à ces préparations pharmaceutiques.

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