Method for determining physiological effects of hemoglobin

G - Physics – 01 – N

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

G01N 33/72 (2006.01) A61K 31/00 (2006.01) A61K 31/04 (2006.01) A61K 31/12 (2006.01) A61K 31/122 (2006.01) A61K 31/18 (2006.01) A61K 31/255 (2006.01) A61K 31/26 (2006.01) A61K 31/381 (2006.01) A61K 31/382 (2006.01) A61K 31/433 (2006.01) A61K 31/465 (2006.01) A61K 31/519 (2006.01) A61K 33/22 (2006.01) A61K 33/26 (2006.01) A61K 33/42 (2006.01) A61K 35/18 (2006.01) A61K 38/42 (2006.01) A61P 7/00 (2006.01)

Patent

CA 2381205

NO preferentially binds to the minor population of the hemoglobin's vacant hemes in a cooperative manner, nitrosylates hemoglobin thiols, or reacts with liberated superoxide in solution. The distribution of minor forms of hemoglobin can be tested and the results can be used to predict whether a composition of hemoglobin will scavenge, load, eliminate, or donate NO. Hemoglobin thus serves to regulate the chemistry of NO. SNO-hemoglobin transfers NO equivalents to the red blood cell anion transport protein AE1, which serves to export NO from red blood cells. Regulation of AE1 function is the basis for methods of therapy to affect levels of NO or its biological equivalent.

Selon cette invention, le monoxyde d'azote NO se lie de préférence à la population mineure d'hèmes vacants de l'hémoglobine de façon coopérative, nitrosyle les thiols d'hémoglobine ou réagit en solution avec le peroxyde libéré. On peut tester la distribution des formes mineures de l'hémoglobine puis utiliser les résultats pour prédire si une composition d'hémoglobine va piéger, charger, éliminer ou rendre NO. Ainsi, l'hémoglobine sert à réguler la chimie de NO. L'hémoglobine SNO transfère les équivalents de NO à la protéine AE1 de transport d'anions des érythrocytes. La régulation de la fonction d'AE1 est à la base des procédés thérapeutiques visant à modifier la teneur en NO ou en son équivalent biologique.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Method for determining physiological effects of hemoglobin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for determining physiological effects of hemoglobin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for determining physiological effects of hemoglobin will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1847462

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.