Method for determining physiological effects of hemoglobin

Details Method for determining physiological effects of hemoglobin Method for determining physiological effects of hemoglobin

G - Physics

01

N

G01N 33/72 (2006.01) A61K 31/00 (2006.01) A61K 31/04 (2006.01) A61K 31/12 (2006.01) A61K 31/122 (2006.01) A61K 31/18 (2006.01) A61K 31/255 (2006.01) A61K 31/26 (2006.01) A61K 31/381 (2006.01) A61K 31/382 (2006.01) A61K 31/433 (2006.01) A61K 31/465 (2006.01) A61K 31/519 (2006.01) A61K 33/22 (2006.01) A61K 33/26 (2006.01) A61K 33/42 (2006.01) A61K 35/18 (2006.01) A61K 38/42 (2006.01) A61P 7/00 (2006.01)

Patent

CA 2381205

NO preferentially binds to the minor population of the hemoglobin's vacant hemes in a cooperative manner, nitrosylates hemoglobin thiols, or reacts with liberated superoxide in solution. The distribution of minor forms of hemoglobin can be tested and the results can be used to predict whether a composition of hemoglobin will scavenge, load, eliminate, or donate NO. Hemoglobin thus serves to regulate the chemistry of NO. SNO-hemoglobin transfers NO equivalents to the red blood cell anion transport protein AE1, which serves to export NO from red blood cells. Regulation of AE1 function is the basis for methods of therapy to affect levels of NO or its biological equivalent.

Selon cette invention, le monoxyde d'azote NO se lie de préférence à la population mineure d'hèmes vacants de l'hémoglobine de façon coopérative, nitrosyle les thiols d'hémoglobine ou réagit en solution avec le peroxyde libéré. On peut tester la distribution des formes mineures de l'hémoglobine puis utiliser les résultats pour prédire si une composition d'hémoglobine va piéger, charger, éliminer ou rendre NO. Ainsi, l'hémoglobine sert à réguler la chimie de NO. L'hémoglobine SNO transfère les équivalents de NO à la protéine AE1 de transport d'anions des érythrocytes. La régulation de la fonction d'AE1 est à la base des procédés thérapeutiques visant à modifier la teneur en NO ou en son équivalent biologique.

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