C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/4745 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C12N 15/09 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2755260
To provide a method for determining the sensitivity of a patient to irinotecan, SN-38, and/or a salt thereof, which method can determine the therapeutic response of the patient and to provide a novel cancer therapeutic means employing the method. The method for determining the sensitivity of a subject to irinotecan, SN-38, and/or a salt thereof includes measuring the expression levels of AMD1 gene, CTSC gene, EIF1AX gene, C12orf30 gene, DDX54 gene, PTPN2 gene, and TBX3 gene in a specimen, and calculating the best tumor response rate (%), overall survival (days), or progression-free survival (days) from formulas (1) to (3).
L'invention concerne un procédé pour déterminer la sensibilité à l'irinotécan, SN-38 et/ou l'un de leurs sels, capable de déterminer la réponse thérapeutique de patients individuels. Elle concerne également un nouveau moyen de traiter le cancer, qui utilise le procédé. L'invention concerne spécifiquement un procédé pour déterminer la sensibilité à l'irinotécan, SN-38 et/ou l'un de leurs sels, qui se caractérise par la mesure du niveau d'expression du gène AMD1, du gène CTSC, du gène EIF1AX, du gène C12orf30, du gène DDX54, du gène PTPN2 et du gène TBX3 dans un échantillon, et le calcul de la meilleure réponse tumorale objective (%), de la survie globale (jours) ou de la survie sans évolution (jours) conformément aux formules (1) à (3).
Hiyama Keiko
Nishiyama Masahiko
Tanimoto Keiji
Kabushiki Kaisha Yakult Honsha
Saitama Medical University
Smart & Biggar
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