Method for determining susceptibility to prion disease

Details Method for determining susceptibility to prion disease Method for determining susceptibility to prion disease

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G01N 33/48 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2454647

This invention relates to a method of determining the susceptibility of a subject to prion disease comprising the steps of: (a) providing a sample from said subject; and (b) determining the human leucocyte antigen specificity of said sample; wherein if said sample has DQ7 human leucocyte antigen specificity, this indicates that said subject has a decreased susceptibility to prion disease; and if said sample does not have DQ7 human leucocyte antigen specificity, this indicates that said subject has an increased susceptibility to prion disease.

L'invention concerne une méthode permettant de déterminer la susceptibilité d'un sujet à une maladie à prion. Ladite méthode consiste a) à fournir un échantillon provenant du sujet; et b) à déterminer la spécificité d'un antigène leucocytaire humain dudit échantillon. Lorsque cet échantillon présente une spécificité d'antigène leucocytaire humain de type DQ7, la susceptibilité du sujet à une maladie à prion diminue, et lorsque cet échantillon ne présente pas de spécificité d'antigène leucocytaire humain de type DQ7, la susceptibilité du sujet à une maladie à prion augmente.

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