C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/26 (2006.01)
Patent
CA 2674704
The present invention provides methods for determining the stability of methyleneamine, methyleneamine-like compounds or compounds containing an methyleneamine moiety in the presence of semicarbazide-sensitive amine oxidase (SSAO) or a biological sample containing SSAO activity. The disclosed methods may be configured in an assay format for high throughput screening applications.
La présente invention concerne des procédés permettant de déterminer la stabilité de la méthylèneamine, de composés similaires à la méthylèneamine ou de composés contenant un groupe méthylèneamine en présence d'une amine oxydase sensible au semicarbazide (SSAO) ou d'un échantillon renfermant une activité SSAO. Les procédés décrits peuvent être configurés dans un format de dosage pour des applications de criblage à haut débit.
Adedoyin Adedayo
Angelastro Michael R.
Bick Julie Ann
Cairns Jennifer
Huang Yongqing
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi Aventis
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