Method for determining the total coagulation activity of a...

G - Physics – 01 – N

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G01N 33/86 (2006.01)

Patent

CA 2598757

The invention relates to a method for determining the total coagulation activity of a blood or plasma sample. Said method is characterised in that a defined quantity of a highly-specific, non-irreversible thrombin inhibitor is added to a blood or plasma sample, the coagulation in the blood or plasma sample is induced, and after a defined period of time, the consumed quantity of the added thrombin inhibitor is determined by methods known per se. The invention also relates to a kit for obtaining information about the coagulation status of a blood sample.

L'invention concerne un procédé servant à déterminer l'activité de coagulation globale d'un échantillon de sang ou de plasma. Le procédé selon l'invention est caractérisé en ce qu'on ajoute en quantité définie un inhibiteur non irréversible et hautement spécifique de la thrombine à un échantillon de sang ou de plasma, en ce qu'on induit la coagulation dans l'échantillon de sang ou de plasma et en ce qu'on détermine de manière connue en soi la quantité utilisée de l'inhibiteur de thrombine ajouté après une durée définie. L'invention concerne également un nécessaire servant à obtenir des indications sur l'état de coagulation d'un échantillon sanguin.

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