Method for determining viability of a myocardial segment

Details Method for determining viability of a myocardial segment Method for determining viability of a myocardial segment

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 31/137 (2006.01) A61K 31/7004 (2006.01) A61K 49/22 (2006.01)

Patent

CA 2383600

A method of determining the viability of a hibernating or stunned myocardial segment comprises the administration of ribose, a vasodilator and an inotropic agent. The preferred agent is dobutamine, which has both a vasodilation and an inotropic effect. The segments may be identified by myocardial imaging by any known means, such as echocardiography, Thallium-201 tracing or positron emission tomography. Ribose is preferably given one minute to three hours prior to administration of the vasodilator and inotropic agents.

L'invention concerne un procédé de détermination de la viabilité d'un segment myocardique en hibernation ou sidéré, qui consiste à administrer le ribose, un vasodilatateur et un agent inotrope. L'agent préféré, la dobutamine, favorise aussi bien la vasodilatation qu'un effet inotrope. Les segments peuvent être identifiés par imagerie myocardique par n'importe quel moyen connu, tel que l'échocardiographie, le tracé au thallium 201 ou la tomographie par émission de positrons. De préférence, le ribose est administré une minute à trois heures avant l'application du vasodilatateur et des agents inotropes.

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