C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/71 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12P 21/08 (2006.01) G01N 33/563 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) C12N 5/16 (2006.01)
Patent
CA 2727365
The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor. The invention provides antibodies or fragments thereof that recognises an epitope of a HER2 receptor truncated form, said epitope being defined by a sequence included in SEQ ID NO: 2. The invention also provides a method of cancer diagnosis, which comprises the detection of the presence of the HER2 receptor truncated form consisting of the amino acid sequence SEQ JD NO: 1 in a patient sample.
La présente invention concerne un procédé destiné au diagnostic et au traitement de cancers exprimant le récepteur HER2. L'invention concerne en particulier des anticorps ou certains de leurs fragments, qui reconnaissent un épitope d'une forme tronquée du récepteur HER2, ledit épitope étant défini par une séquence incluse dans SEQ ID NO: 2. L'invention concerne également un procédé de diagnostic de cancer consistant à détecter dans un échantillon prélevé sur un patient la présence de la forme tronquée du récepteur HER2 constituée de la séquence d'acides aminés SEQ ID NO: 1.
Angellini Pier-Davide
Arribas Lopez Joaquin
Baselga Torres Jose
Laos Sirle
Parra Palau Josep Lluis
Fasken Martineau Dumoulin Llp
Fundacio Privada Institucio Catalana de Recerca I. Estudis Avanc
Fundacio Privada Institut D'investigacio Oncologica de Vall Hebr
Fundacio Privada Institut de Recerca Hospital Universitari Vall
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