C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 35/00 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) C07K 14/47 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2500470
Objective methods for detecting and diagnosing Chronic myeloid leukemia (CML) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of CML-associated gene that discriminate between CML and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of CML, methods of treating CML and method of vaccinating a subject against CML.
L'invention concerne des procédés objectifs de détection et de diagnostic de leucémie myéloïde chronique (CML). Dans un mode de réalisation, le procédé de diagnostic consiste à déterminer le niveau d'expression d'un gène associé à cette maladie qui réalise une discrimination entre une cellule normale et une cellule CML. Elle concerne aussi des procédés de criblage d'agents thérapeutiques utiles dans le traitement de la CML, des méthodes de traitement de la CML et un procédé de vaccination d'un sujet contre la CML.
Katagiri Toyomasa
Nakamura Yusuke
Bereskin & Parr
Oncotherapy Science Inc.
The University Of Tokyo
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