G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2399067
The invention provides methods for diagnosing the efficacy of a patient to xenotypic antibody therapy which include (1) measuring the level of an antibody produced by a patient that specifically binds to a xenotypic antibody after administration of the xenotypic antibody to the patient; (2) measuring the level of an anti-idiotype antibody produced by a patient that specifically binds to a xenotypic antibody after administration of the xenotypic antibody to the patient; (3) measuring the level of an antibody produced by a patient that specifically binds to a target antigen of a xenotypic antibody after administration of a xenotypic antibody to the patient; and (4) measuring the level of a T cell response produced by a patient to a target antigen of the xenotypic antibody after administration of a xenotypic antibody to the patient. In the methods of the invention, an increase in the level of antibody or T cell response produced by the patient after the administration of the xenotypic antibody relative to the level antibody or T cell response produced by the patient prior to the administration of the xenotypic antibody is indicative of a favorable diagnosis of efficacy.
Cette invention concerne des méthodes permettant d'évaluer l'efficacité chez un patient d'une thérapie par anticorps xénotypiques qui consiste à : (1) mesurer chez un patient le niveau d'anticorps se liant spécifiquement à un anticorps xénotypique après administration d'un tel anticorps audit patient ; (2) mesurer chez un patient le niveau d'un anticorps anti-idiotype se liant spécifiquement à un anticorps xénotype après administration de anticorps xénotypique audit patient ; (3) mesurer chez un patient le niveau d'un anticorps se liant spécifiquement à un antigène cible d'un anticorps xénotype après administration d'un anticorps xénotypique audit patient ; et (4) mesurer chez un patient le niveau de réponse de lymphocytes T à un antigène cible de l'anticorps xénotypique après administration d'un anticorps xénotypique audit patient. Les méthodes décrites dans l'invention montrent qu'une augmentation du niveau d'anticorps ou de réponse des cellules T chez un patient après administration de l'anticorps xénotypique par rapport au niveau d'anticorps ou de réponse de lymphocytes T chez ce patient avant administration de l'anticorps xénotypique permet d'augurer un diagnostic favorable.
Noujaim Antoine
Altarex Corp.
Altarex Medical Corp.
Parlee Mclaws Llp
LandOfFree
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