G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/53 (2006.01) G01N 33/564 (2006.01)
Patent
CA 2738952
The present invention provides methods of diagnosing and monitoring systemic lupus erythematosus and drug-induced lupus erythematosus by measuring cell-based complement activation products in a subject's blood. In particular, the invention describes a diagnostic method employing the measurement of multiple complement activation products, such as C3d and C4d, on the surfaces of red blood cells, white blood cells, and platelets. Kits and automated systems for performing the methods of the invention are also disclosed.
L'invention concerne des méthodes de diagnostic et de surveillance du lupus érythémateux systémique et du lupus érythémateux systémique induit par des médicaments par mesure de produits d'activation de complément dans le sang d'un sujet. L'invention concerne en particulier un procédé de diagnostic utilisant la mesure de produits d'activation de complément multiples, tels que C3d et C4d, sur les surfaces des globules rouges, des globules blancs et des plaquettes. L'invention concerne également des kits et des systèmes automatisés pour exécuter les méthodes de l'invention.
Ahearn Joseph M.
Erickson Edward L.
Hawkins Douglas
Manzi Susan M.
Cypress Bioscience Inc.
Smart & Biggar
University Of Pittsburgh
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