A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) A61P 37/08 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2421274
The present invention discloses methods for immunizing against autologous (self) Immunoglobulin E (IgE). In particular, the invention discloses methods for inducing cytotoxic T-lymphocytes that will specifically down-regulate B- cells producing autologous IgE, notably by means of nucleic acid vaccination or live vaccination. Also disclosed are methods for inducing antibodies reactive with autologous IgE as well as methods for inducing a combined antibody and CTK response specific for IgE. The invention also discloses specific immunogenic protein constructs, nucleic acids encoding these as well as various formulations and tools for preparing the vaccines, including vectors and transformed host cells.
L'invention concerne des procédés d'immunisation contre les immunoglobines E (IgE) autologues. En particulier, l'invention concerne des procédés visant à induire des lymphocytes T cytotoxiques qui régulent négativement les lymphocytes B produisant les IgE autologues, notamment au moyen d'une vaccination à acide nucléique ou d'une vaccination à viru vivant. L'invention concerne aussi des procédés visant à induire des anticorps réagissant avec les IgE autologues, et des procédés visant à induire un anticorps combiné et une réponse de CTK spécifique d'IgE. L'invention concerne en outre des protéines chimères immunogènes spécifiques, des acides nucléiques codant pour celles-ci ainsi que diverses formulations et outils utiles pour la préparation de vaccins, ainsi que des vecteurs et des cellules hôtes transformées.
Gautam Anand
Hoegen Paul von
Klysner Steen
Voldborg Bjorn
Pharmexa A/s
Sim & Mcburney
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