Method for down-regulating osteoprotegerin ligand activity

Details Method for down-regulating osteoprotegerin ligand activity Method for down-regulating osteoprotegerin ligand activity

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 38/19 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 19/10 (2006.01) A61P 37/04 (2006.01) C12N 15/62 (2006.01) G01N 33/50 (2006.01) C07K 14/52 (2006.01) C07K 14/525 (2006.01) C07K 14/705 (2006.01) C12N 1/21 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2343654

The invention provides a novel method for down-regulating the biological activity of osteoprotegerin ligand (OPGL, TRANCE) thereby rendering possible the treatment/amelioration of diseases characterized by excessive loss of bone mass, e.g. osteoporosis. Down-regulation is effected by inducing an immune response against OPGL in an individual in need thereof. Immune responses can be raised by classical immunization with immunogenic variants of OPGL or by nucleic acid immunization where the nucleic acids encode the OPGL variant. The invention also pertains to compositions, polypeptides and nucleic acids useful in the invention, as well as to vectors and transformed host cells useful in the preparation thereof.

L'invention porte sur un nouveau procédé de régulation négative de l'activité biologique du ligand d'ostéoprotégérine (OPGL, TRANCE), ce procédé permettant de traiter/guérir les maladies caractérisées par une perte excessive de la masse osseuse telles que l'ostéoporose. Pour effectuer une régulation négative, on induit une réponse immune contre OPGL chez un individu malade. Les réponses immunes peuvent être augmentées par une immunisation classique avec des variantes immunogènes d'OPGL ou par immunisation des acides nucléiques, ces acides nucléiques codant la variante d'OPGL. L'invention porte également sur des compositions, des polypeptides et des acides nucléiques, ainsi que sur des vecteurs et des cellules hôtes transformées utiles dans la préparation de ces compositions.

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