A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01)
Patent
CA 2545677
A liposome composition having a protonatable therapeutic agent entrapped in the form of a salt with an glucuronate anion is disclosed. Methods for preparing the composition using an ammonium ion transmembrane gradient having glucuronate as the counterion are also disclosed. In one embodiment where the protonatable agent is doxorubicin, the method of the invention has comparable loading efficiency, faster release rate, without compromising the therapeutic efficacy compared to loading with an ammonium ion gradient having sulfate as the counterion.
L'invention concerne une composition de liposomes présentant un agent thérapeutique pouvant être protoné emprisonné sous forme de sel avec un anion de glucuronate. L'invention concerne des procédés pour préparer la composition au moyen d'un gradient transmembranaire d'ions ammonium présentant du glucuronate comme contre-ions. Dans un mode de réalisation, dans lequel l'agent thérapeutique pouvant être protoné est la doxorubicine, le procédé de l'invention présente une efficacité de chargement analogue, un taux de libération plus rapide, tout en ne compromettant par l'efficacité thérapeutique comparée au chargement au moyen du gradient d'ions ammonium comprenant du sulfate comme contre-ions.
Barenholz Yechezkel
Gabizon Alberto A.
Gowling Lafleur Henderson Llp
Yissum Research Development Company Of The Hebrew University Of
LandOfFree
Method for drug loading in liposomes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for drug loading in liposomes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for drug loading in liposomes will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1563484