Method for electroelution of a biological sample and...

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Details

204/99.04

G01N 27/447 (2006.01) B01D 57/02 (2006.01) C12N 15/10 (2006.01) C12Q 1/68 (2006.01) G01N 1/34 (2006.01)

Patent

CA 2328298

The invention concerns a method for treating by the action of an electric field in liquid medium a biological sample comprising both a nucleic material and a non-nucleic material, which consists in: a) providing a buffer solution; b) providing a permeable membrane, in contact on one side with the buffer solution, and having a predetermined interrupting threshold to stop the nucleic material, on said buffer solution side, when it is migrating under the action of the electric field; c) generating said electric field; d) placing the biological sample in the buffer solution, upstream of the membrane, along the nucleic material circulating direction by the electric field action. The invention is characterised in that it consists in: directly applying the electric field to the biological sample in the buffer solution, for a limited time interval determined by sufficient time for the nucleic material to arrive on the membrane and by its presence on the buffer solution side, and by the fact that at said time interval end the non-nucleic material has not migrated and/or is still in the process of migrating towards said membrane; removing the nucleic material after said time interval, and thereby electroeluting from the biological sample at least the nucleic material. The invention also concerns the implementing device.

Procédé de traitement sous l'action d'un champ électrique en milieu liquide, d'un échantillon biologique comprenant à la fois un matériel nucléique et un matériel non nucléique: a) on dispose d'une solution tampon; b) on dispose d'une membrane perméable, en contact d'un côté avec la solution tampon, et ayant un seuil de coupure prédéterminé pour arrêter le matériel nucléique, du côté de ladite solution tampon, lors de sa migration sous l'action du champ électrique; c) on établit ledit champ électrique; d) on dispose l'échantillon biologique dans la solution tampon, en amont de la membrane, selon le sens de circulation du matériel nucléique sous l'action du champ électrique; caractérisé en ce que: on applique le champ électrique directement à l'échantillon biologique dans la solution tampon, pendant une durée limitée et définie, d'une part par le temps suffisant pour l'arrivée sur la membrane et la présence de matériel nucléique du côté de la solution tampon, et d'autre part par le fait qu'au terme de ladite durée le matériel non nucléique n'a pas migré et/ou demeure en cours de migration vers ladite membrane; on prélève le matériel nucléique au terme de ladite durée, moyennant quoi on électro-sépare de l'échantillon biologique au moins le matériel nucléique, et dispositif pour le mettre en oeuvre.

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