Method for enantioselective hydrogenation of chromenes

Details Method for enantioselective hydrogenation of chromenes Method for enantioselective hydrogenation of chromenes

C - Chemistry, Metallurgy

07

D

C07D 311/02 (2006.01)

Patent

CA 2617665

A method for preparing an enantiomeric chromane, by asymmetrically hydrogenating a chromene compound in the presence of an Ir catalyst having a chiral ligand. The method includes the enantioselective preparation of enantiomeric equol. A preferred Ir catalyst has a chiral phosphineoxazoline ligand. Enantiomeric chromanes of high stereoselective purity can be obtained.

L'invention porte sur un procédé de préparation d'un chromane énantiomère par hydrogénation asymétrique d'un composé chromène en présence d'un catalyseur Ir possédant un ligand chiral. Le procédé comprend la préparation énantiosélective d'équol énantiomère. Un catalyseur Ir préféré possède un ligand de phosphineoxazoline chiral. Il est ainsi possible d'obtenir des chromanes énantiomères de haute pureté stéréosélective.

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