Method for encapsulating therapeutic substances in cells

Details Method for encapsulating therapeutic substances in cells Method for encapsulating therapeutic substances in cells

A - Human Necessities

61

K

A61K 9/50 (2006.01) A61K 9/00 (2006.01) A61K 33/26 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) A61N 1/40 (2006.01)

Patent

CA 2619278

The invention relates to compositions containing nanoparticles and to uses of said compositions for encapsulating therapeutically active substances in cells by means of nanoparticles with a particular coating. The particles are chemically formed in such a way as to enable a high intracellular absorption into the cells. The encapsulation requires no direct binding between nanoparticles and the therapeutically active substance. The encapsulation enables an increased efficiency of the substance with a simultaneously low systemic toxicity, therefore an increase in efficiency with simultaneous reduction of side effects.

L'invention concerne des compositions contenant des nanoparticules et des utilisations de ces compositions pour l'encapsulage de substances thérapeutiques dans des cellules à l'aide de nanoparticules présentant un revêtement particulier. Les particules ont une conception chimique telle que l'absorption intracellulaire est importante dans les cellules. L'encapsulage ne requiert par de liaison directe entre les nanoparticules et la substance thérapeutique. L'encapsulage permet d'obtenir une grande efficacité de la substance tout en maintenant une toxicité systémique basse, c.-à-d. une hausse de l'efficacité et une réduction simultanée des effets secondaires.

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