Method for enhancing and/or accelerating immunoassay...

Details Method for enhancing and/or accelerating immunoassay... Method for enhancing and/or accelerating immunoassay...

C - Chemistry, Metallurgy

12

Q

167/45

C12Q 1/00 (2006.01) C07K 16/30 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/531 (2006.01)

Patent

CA 1270194

ABSTRACT Detection of an identified human carcinoma tumor antigen in a pathological sample by means of a labelled monoclonal antibody specific to the determinant site on the antigen is enhanced and/or accelerated at an ear- lier developmental stage than heretofore achieved by removing a carbohydrate steric hinderance for monoclonal antibody availability to bind the antigen of the tumor for which it is specific. The carbohydrate steric hindrance for monoclonal binding to the antigen is identified as sialic acid. The method of the invention involves selective removal of sialic acid from the antigen's determinant site by enzymatic digestion using neuraminidase.

516421

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