Method for enhancing dissolution properties of relatively...

A - Human Necessities – 61 – K

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A61K 47/10 (2006.01) A23L 1/30 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/122 (2006.01) A61K 45/06 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2236023

A method for enhancing the dissolution properties of relatively insoluble dietary supplements is provided in accordance with the invention. The method includes the steps of providing at least one relatively water-insoluble dietary supplement, solubilizing the dietary supplement with a solubilizer, and incorporating an edible polyhydric alcohol into the solubilized dietary supplement to provide a liquid dietary supplement composition that will dissolve spontaneously in the gastrointestinal tract with the minimum agitation which normally occurs there due to peristaltic action. The liquid dietary supplement composition can be readily supplied by incorporation in a gelatin capsule and a gelatin capsule having a liquid dietary supplement incorporated therein is also provided in accordance with the invention. The gelatin capsule dissolves readily in the digestive tract and the dietary supplement has enhanced bioavailability in comparison to prior art gelatin capsules.

Cette invention se rapporte à un procédé d'accentuation des caractéristiques de dissolution de compléments alimentaires relativement insolubles. Ledit procédé consiste à utiliser au moins un complément alimentaire relativement insoluble dans l'eau, à dissoudre ledit complément alimentaire avec un agent de solubilisation, et à incorpore un alcool polyhydrique comestible dans le complément alimentaire solubilisé de façon à obtenir une composition liquide de complément alimentaire susceptible de se dissoudre spontanément dans le tractus gastro-intestinal sous l'action de l'agitation minimum se produisant normalement en raison de l'effet péristaltique. On peut facilement administrer ladite composition liquide de complément alimentaire en l'incorporant à une capsule de gélatine. L'invention se rapporte également à une capsule de gélatine contenant un complément alimentaire liquide. Ladite capsule de gélatine se dissout rapidement dans le tractus digestif et le complément alimentaire possède une assimilabilité accrue en comparaison des capsules de gélatines fabriquées selon des procédés conformes à l'état antérieur de la technique.

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