Method for enhancing immune responses in mammals

Details Method for enhancing immune responses in mammals Method for enhancing immune responses in mammals

A - Human Necessities

61

K

A61K 35/14 (2006.01) A61K 39/00 (2006.01) A61M 1/36 (2006.01) A61P 37/04 (2006.01) C07K 16/28 (2006.01) A61K 35/00 (2006.01) A61M 1/34 (2006.01)

Patent

CA 2392137

The present invention provides a method for enhancing an immune response in a mammal to facilitate the elimination of a chronic pathology. The method involves the removal of immune system inhibitors from the circulation of the mammal, thus, enabling a more vigorous immune response to the pathogenic agent. The removal of immune system inhibitors is accomplished by contacting an acellular component of whole blood, or a fraction thereof, of a mammal with one or more binding partner(s) capable of binding to and, thus, depleting the targeted immune system inhibitor(s) from the biological fluids. Particularly useful in the invention is an absorbent matrix composed of an inert, biocompatible substrate joined covalently to a binding partner, such as an antibody, capable of specifically binding to the targeted immune system inhibitor.

La présente invention concerne un procédé permettant d'améliorer une réponse immunitaire chez un mammifère afin de faciliter l'élimination d'une pathologie chronique. Le procédé consiste à enlever les inhibiteurs de système immunitaire de la circulation sanguine du mammifère, procurant ainsi une réponse immunitaire plus puissante vis à vis de l'agent pathologique. L'enlèvement des inhibiteurs de système immunitaires s'effectue par le contact d'une composante acellulaire de sang entier, ou d'une fraction de celui-ci, du mammifère avec une ou des partenaire(s) de liaison capable de liaison, permettant ainsi d'effectuer une déplétion des inhibiteurs ciblés dans les fluides biologiques. L'invention est caractérisée en ce qu'elle comporte une matrice d'absorption composée d'un support biocompatible inerte liée de manière covalente à une partenaire de liaison, tel un anticorps, capable de se lier spécifiquement à l'inhibiteur de système immunitaire ciblé.

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