A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/14 (2006.01) A23D 9/00 (2006.01) A23L 1/30 (2006.01) A23L 1/302 (2006.01) A23L 1/303 (2006.01) A61K 31/07 (2006.01) A61K 31/20 (2006.01) A61K 31/355 (2006.01) C11C 3/10 (2006.01)
Patent
CA 2315224
This invention relates to a method for enhancing the absorption of oil soluble (lipophilic) compounds such as oil soluble vitamins, hormones, nutrients and drugs in an animal. The inventive method comprises administering a lipophilic compound in conjunction with a structured glyceride component characterized in that at least 40 % of the glyceride species have: (i) about 33 to 70 wt% of acyl moieties having 4 to 12 carbon atoms; (ii) about 30 to 67 wt% of acyl moieties having more than 12 carbon atoms; and (iii) an equivalent carbon number greater than 30 and less than 48. This invention also relates to compositions suitable for administrating to an animal comprising a lipophilic compound and a structured glyceride component characterized in that at least 40 % of the glyceride species have: (i) about 33 to 70 wt% of acyl moieties having 4 to 12 carbon atoms; (ii) about 30 to 67 wt% of acyl moieties having more than 12 carbon atoms; and (iii) an equivalent carbon number greater than 30 and less than 48. The method and compositions of the invention are especially suited for animals that suffer from lipid malabsorption conditions such as Crohn's disease, Cystic fibrosis, and short bowel syndrome.
L'invention porte sur un procédé renforçant l'absorption par l'animal de composés liposolubles (lipophiles) tels que des vitamines, des hormones, des nutriments et des médicaments liposolubles, consistant à lui administrer un composé lipophile associé à un composant structuré de glycérides dont 40 % au moins présente: (i) d'environ 33 à 70 % en poids de fragments d'acyle à 4 à 12 atomes de carbone; (ii) d'environ 30 à 67 % en poids de fragments d'acyle à plus de 12 atomes de carbone; (iii) et un nombre équivalent d'atomes de carbone supérieur à 30 et inférieur à 48. L'invention porte également sur des compositions administrables à l'animal comportant un composant structuré de glycérides caractérisé dont 40 % au moins présente: (i) d'environ 33 à 70 % en poids de fragments d'acyle à 4 à 12 atomes de carbone; (ii) d'environ 30 à 67 % en poids de fragments d'acyle à plus de 12 atomes de carbone; (iii) et un nombre équivalent d'atomes de carbone supérieur à 30 et inférieur à 48. Les procédés et compositions de l'invention s'adressent spécialement aux animaux souffrant de troubles de l'absorption, tels que la maladie de Crohn's, la fibrose cystique, ou le syndrome de l'intestin court.
Demichele Stephen J.
Lee Theresa W.
Tso Patrick
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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