Method for enhancing the solubility of substantially...

A - Human Necessities – 61 – K

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A61K 47/38 (2006.01) A61K 31/18 (2006.01) A61K 31/19 (2006.01) A61K 31/425 (2006.01) A61K 31/54 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2247410

Methods for enhancing the water-solubility of substantially water-insoluble compounds are disclosed by combining such compounds with a water-soluble polymer, e.g., polyalkylene oxide polymer or a cellulose ether, having a molecular weight of from about 50,000 to 7,000,000 grams/per gram in an amount effective to enhance the water-solubility of the compound in an acidic environment, e.g., pH less than about 5. Compositions comprising the compounds having enhanced water solubility are also disclosed.

Cette invention concerne des procédés pouvant améliorer la solubilité de composés sensiblement insolubles dans l'eau, par combinaison desdits composés avec un polymère soluble dans l'eau, par exemple un polymère de polyoxyde d'alkylène ou un éther de cellulose, ayant un poids moléculaire compris entre environ 50 000 et 7 000 000 grammes par gramme dans une quantité effective pour améliorer la solubilité desdits composés dans l'eau, en milieu acide à un pH inférieur à environ 5, par exemple. L'invention concerne également des compositions contenant les composés ayant une solubilité dans l'eau améliorée.

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