Method for enzymatic production of glp-1 (7-36) amide peptides

Details Method for enzymatic production of glp-1 (7-36) amide peptides Method for enzymatic production of glp-1 (7-36) amide peptides

C - Chemistry, Metallurgy

07

K

C07K 14/605 (2006.01) C07K 1/34 (2006.01) C12P 21/06 (2006.01)

Patent

CA 2485701

The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.

L'invention concerne des méthodes d'obtention de peptides à partir d'un polypeptide renfermant au moins une copie de peptide, consistant à exciser le peptide du polypeptide à l'aide de clostripaïne. Ces méthodes permettent d'utiliser un seul clivage enzymatique de grande efficacité pour produire n'importe quel séquence peptidique.

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