Method for evaluating compound using molecule on the rb...

Details Method for evaluating compound using molecule on the rb... Method for evaluating compound using molecule on the rb...

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2618657

It is intended to provide a molecule which is present on the Rb pathway and can be used as a drug discovery target for an anticancer agent or a tumor marker and a method capable of evaluating a compound (a candidate compound for an anticancer agent) using the molecule. The object can be achieved by a method for evaluating a compound which detects the interaction between IL-8, IL-8 receptor, ECT2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, CCNE2, FEN1, HMGB2, CENPE, KIF20A, CDC25C, CDCA8, KIF11, HCAP-E, HCAP-G, KNTC2, HCAP-C, BUB1, NEK2, CCNA2 or KIF18A gene or protein and a test compound.

L~invention entend proposer une molécule présente sur le trajet Rb et pouvant s~utiliser comme cible de découverte de médicament pou agent anticancéreux ou marqueur de tumeur ainsi qu~un procédé capable d~évaluer un composé (candidat composé pour agent anticancéreux) utilisant la molécule. L~objet peut être satisfait grâce à un procédé d~évaluation d~un composé qui détecte l~interaction entre IL-8, le récepteur IL-8, ECT2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, CCNE2, FEN1, HMGB2, CENPE, KIF20A, CDC25C, CDCA8, KIF11, HCAP-E, HCAP-G, KNTC2, HCAP-C, BUB1, NEK2, CCNA2 ou KIF18A comme gène ou protéine et un composé de test.

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