Method for evaluating the ability to metabolize...

C - Chemistry – Metallurgy – 07 – H

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C07H 21/04 (2006.01) C12N 9/02 (2006.01) C12P 19/34 (2006.01) C12Q 1/44 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2439403

Methods for detecting variant genes having a polymorphism associated with reduced metabolism of a substrate selected from the group consisting of a CYP3A4 substrate, a CYP3A5 substrate and a GSTM1 substrate in an individual are disclosed. The methods are genotyping methods to identify specific polymorphisms which heve been found to be associated with reduced metabolism of chemotherapeutic agents, such as cyclophosphamide and BCNU. Also disclosed are novel polymorphic nucleic acid molecules useful in the methods of the invention.

L'invention concerne des procédés de détection de gènes de variants présentant un polymorphisme associé à un métabolisme réduit d'un substrat sélectionné dans le groupe renfermant un substrat CYP3A4, un substrat CYP3A5 et un substrat GSTM1 chez un individu. Les procédés sont des procédés de génotypage permettant d'identifier des polymorphismes spécifiques dont on a découvert l'association avec un métabolisme réduit d'agents chimiothérapeutiques, tels qu'un cyclophosphamide et un BCNU. L'invention concerne également des nouvelles molécules d'acides nucléiques polymorphes utiles dans les procédés selon l'invention.

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