Method for evaluating the response of an individual to a...

Details Method for evaluating the response of an individual to a... Method for evaluating the response of an individual to a...

C - Chemistry, Metallurgy

12

Q

C12Q 1/70 (2006.01)

Patent

CA 2674880

The present invention relates to a method for evaluating the in vivopresence of a factor that prevents the biological effect of a type I (IFN) in an individual that is under treatment with said type I interferon. In particular, the present invention relates to a method for evaluating the in vivo presence of antibodies directed against a type I interferon (IFN) in an individual that is under treatment with said type I interferon. The method comprises incubating a blood sample of said individual in vitrowith a suitable amount of said type I interferon for a suitable period of time, and determining mRNA levels of a biological marker of IFN activity, preferably MxA, in said blood sample. The treatment mayinvolve a treatment of multiple sclerosis, HCV or HBV using a type I interferon.

La présente invention concerne un procédé d'évaluation de la présence in vivo d'un facteur qui empêche l'effet biologique d'un interféron (IFN) de type I chez un individu qui subit un traitement par ledit interféron de type I. La présente invention concerne notamment un procédé d'évaluation de la présence in vivo d'anticorps dirigés contre un interféron (IFN) de type I chez un individu qui subit un traitement par ledit interféron de type I. Le procédé comprend l'incubation d'un échantillon de sang dudit individu in vitro avec une quantité appropriée dudit interféron de type I pendant une durée appropriée et la détermination des niveaux d'ARNm d'un marqueur biologique de l'activité de l'IFN, de préférence MxA, dans ledit échantillon de sang. Le traitement peut comprendre un traitement de la sclérose en plaques, du VHC ou du VHB utilisant un interféron de type I.

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