C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/102 (2006.01) C07K 1/113 (2006.01) C07K 1/16 (2006.01) C07K 14/01 (2006.01) C07K 14/285 (2006.01) C12N 15/62 (2006.01) C12N 15/70 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2167808
The present invention relates, in general, to a method of expressing the outer membrane protein P2 from Haemophilus influenzae type b (Hib-P2) and fusion proteins thereof. In particular, the present invention relates to a method of expressing the outer membrane protein P2 from Haemophilus influenzae type b or fusion protein thereof in E. coli wherein the Hib-P2 protein or fusion protein comprises more than 2 % of the total protein expressed in E. coli. The invention also relates to a method of purification and refolding of Hib-P2 protein and fusion protein thereof.
L'invention concerne, d'une manière générale, un procédé d'expression de la proteine de membrane externe P2 à partir de l'haemophilus influenzae de type b (Hib-P2) et leurs protéines de fusion. L'invention porte, plus spécifiquement, sur un procédé d'expression de la protéine de membrane externe P2 à partir de l'haemophilus influenzae de type b ou de leur protéine de fusion dans E. coli, la protéine Hib-P2 ou la protéine de fusion représentant plus de 2 % de la protéine totale exprimée dans E. coli. L'invention se rapporte également à un procédé de purification et de repliement de la protéine Hib-P2 et de sa protéine de fusion.
Blake Milan S.
Liang Shu-Mei
Pullen Jeffrey K.
Soper Thomas S.
Tai Joseph Y.
Baxter Healthcare S.a.
Mbm Intellectual Property Law Llp
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