A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/19 (2006.01) A61J 3/02 (2006.01)
Patent
CA 2508279
This invention relates generally to the freeze-drying of formulations comprising a polynucleotide, a block copolymer and a cationic surfactant. In the presence of a cryoprotectant or bulking agent, a formulation can be freeze- dried, whereby upon reconstitution of the dried formulation, the microparticles maintain their optimal size and aggregation or fusion is avoided.
De manière générale, la présente invention a trait à la lyophilisation de préparations comprenant un polynucléotide, un copolymère séquencé et un tensioactif cationique. Il est possible d'effectuer la lyophilisation d'une préparation, en présence d'un cryoprotecteur ou d'un agent gonflant, permettant, lors de la reconstitution de la formulation lyophilisée, le maintien de la dimension optimales des microparticules et d'éviter l'agrégation ou la fusion.
Mbm Intellectual Property Law Llp
Vical Incorporated
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