Method for gene transfer into target cells with retrovirus

Details Method for gene transfer into target cells with retrovirus Method for gene transfer into target cells with retrovirus

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) C07K 14/50 (2006.01) C07K 14/505 (2006.01) C07K 14/78 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01) C12N 15/12 (2006.01) C12N 15/18 (2006.01) C12N 15/86 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2235629

A method for elevating the gene introduction efficiency into target cells by a retrovirus which comprises infecting the target cells with the retrovirus in the presence of a mixture of an effective amount of a functional substance having a retrovirus-binding site with an effective amount of another functional substance having a target cell-binding site, or in the presence of an effective amount of a functional substance having both of these binding sites in a single molecule. The functional substances are optionally immobilized on beads, etc. This method is usable in, for example, gene therapy.

On décrit un procédé destiné à augmenter l'efficacité d'introduction de gènes dans des cellules cibles, au moyen d'un rétrovirus, et qui consiste à infecter les cellules cibles à l'aide du rétrovirus, soit en présence d'un mélange d'une quantité efficace d'une substance fonctionnelle présentant un site de fixation de rétrovirus et d'une quantité efficace d'une autres substance fonctionnelle présentant un site de fixation de cellule cible, soit en présence d'une quantité efficace d'une substance fonctionnelle présentant ces deux sites de fixation dans une seule molécule. Ces substances fonctionnelles sont éventuellement immobilisées sur des perles, etc.. On peut utiliser ce procédé, par exemple, en thérapie génique.

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