Method for gene transfer using bcl2 and compositions useful...

Details Method for gene transfer using bcl2 and compositions useful... Method for gene transfer using bcl2 and compositions useful...

C - Chemistry, Metallurgy

12

N

C12N 15/64 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/505 (2006.01) C07K 14/705 (2006.01) C07K 14/81 (2006.01) C12N 15/12 (2006.01) C12N 15/18 (2006.01) C12N 15/52 (2006.01) C12N 15/65 (2006.01) C12N 15/86 (2006.01) C12N 15/864 (2006.01) C12N 15/87 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2304131

A method for liver-directed gene therapy is described. The method involves transfer of Bcl2 and a selected transgene to hepatocytes. Bcl2 protects those hepatocytes which express it from apoptosis and permits proliferation of hepatocytes containing the transgene.

L'invention concerne un procédé utile pour une thérapie génique visant le foie. Le procédé comporte l'étape consistant à transférer Bcl2 et un transgène sélectionné vers des hépatocytes. Bcl2 protège les hépatocytes qui l'expriment contre l'apoptose, et permet une prolifération d'hépatocytes contenant le transgène.

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