Method for generating and screening useful peptides

Details Method for generating and screening useful peptides Method for generating and screening useful peptides

C - Chemistry, Metallurgy

12

P

C12P 21/00 (2006.01) B01D 61/14 (2006.01) C07K 1/12 (2006.01) C12M 1/40 (2006.01) C12P 21/06 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01) G01N 33/72 (2006.01)

Patent

CA 2116013

2116013 9304079 PCTABS00020 The invention allows the generation and screening of a large population of peptides for the presence of peptides which bind a particular macromolecule or macromolecular complex with high affinity, and further allows the favored net synthesis of analyzable quantities of such peptides, by using as the "trap" a macromolecule or macromolecular complex for which binding of the peptide is desired. The starting mixture is preferably spiked with a peptide having some affinity for the target macromolecule so that mutation of the spike or "lead" peptide is favored.

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