C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) C07K 16/00 (2006.01) C12N 5/26 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2104415
ABSTRACT OF THE INVENTION This invention relates to a method for producing rabbit monoclonal antibodies employing a stable xenogeneic fusion partner. The stable xenogeneic fusion partner is a product of the fusion of a rodent myeloma cell and a non- transformed rabbit partner cell. A method for generating rabbit monoclonal antibodies is disclosed that comprises fusing a nontransformed rabbit partner cell with a rodent myeloma cell to produce a xenogeneic fusion partner, selecting a stable fusion partner producing undetectable levels of antibodies, fusing the stable fusion partner with a rabbit antibody producing cell and isolating an antibody producing cell line that produces antibodies directed to a predetermined antigen.
Liu Ru-Shya
Manetta Joseph V.
Mccormack Robert T.
Sportsman John R.
Gowling Lafleur Henderson Llp
Hybritech Incorporated
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