Method for generating primate trophoblasts

Details Method for generating primate trophoblasts Method for generating primate trophoblasts

C - Chemistry, Metallurgy

12

Q

C12Q 1/02 (2006.01) C12N 5/073 (2010.01) A61K 38/18 (2006.01)

Patent

CA 2478987

The first method to cause a culture of human and other primate stem cells to directly and uniformly differentiate into a committed cell lineage is disclosed. Treatment of primate stem cells with a single protein trophoblast induction factor causes the cells to transform into human trophoblast cells, the precursor cells of the placenta. Several protein factors including bone morphogenic protein 4 (BMP4), BMP2, BMP7, and growth and differentiation factor 5 can serve as trophoblast-inducting factors.

L'invention concerne un premier procédé permettant d'obtenir une culture de cellules souches d'humains et d'autres primates afin de différencier directement et uniformément un lignage de cellules déterminé. Le traitement des cellules souches de primates à l'aide d'un seul facteur protéique d'induction de trophoblastes transforme les cellules en cellules trophoblastes humaines, cellules précurseurs du placenta. Plusieurs facteurs protéiques comprenant une protéine morphogénique osseuse 4 (BMP4), BMP2, BMP7 et un facteur de différenciation et de croissance (5) peuvent servir de facteurs d'induction de trophoblastes.

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