Method for genetic immunization by electrotransfer against a...

A - Human Necessities – 61 – K

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A61K 39/08 (2006.01) A61K 31/7088 (2006.01)

Patent

CA 2617082

The invention concerns a method for obtaining an antiserum directed against a proteinic toxin by administering to an animal a solution comprising a genetic construct encoding a toxin immunogenic fragment, then applying an electric field in the administering zone, and isolating the serum. The invention also concerns the antiserum obtainable by the method as well as the use of the solution for making a medicine for preventing or treating a toxic effect related to absorption by a mammal of a toxin. The invention is characterized in that said medicine is formulated to be administered by electrotransfer.

L'invention a pour objet un procédé d'obtention d'un antisérum dirigé contre une toxine protéique par administration chez un animal d'une solution comprenant une construction génétique codant un fragment immunogène de toxine, suivie de l'application d'un champ électrique dans la zone d'administration, et isolement du sérum. L'antisérum susceptible d'être obtenu par le procédé ainsi que l'utilisation de la solution pour la fabrication d'un médicament destiné à prévenir ou à traiter un effet toxique lié à l'absorption chez un mammifère d'une toxine, caractérisée en ce que ledit médicament est formulé en vue d'une administration par électrotransfert, sont également compris dans l'invention.

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