Method for grafting a substituted difluoromethyle group

Details Method for grafting a substituted difluoromethyle group Method for grafting a substituted difluoromethyle group

C - Chemistry, Metallurgy

07

C

C07C 313/04 (2006.01) B01J 19/12 (2006.01) C07B 45/00 (2006.01) C07B 45/06 (2006.01) C07C 303/02 (2006.01) C07C 303/14 (2006.01) C07C 309/04 (2006.01) C07C 319/14 (2006.01) C07C 319/20 (2006.01) C07C 323/09 (2006.01) C07C 309/80 (2006.01) C07C 323/03 (2006.01)

Patent

CA 2262499

The invention concerns a method for grafting a substituted difluoromethyle group on a compound containing at least one electrophilic function, comprising the following steps: i) bringing said compound containing at least one electrophilic function in the presence of one nucleophilic reagent containing: a) a fluorocarboxylic acid of formula Ea - CF¿2? - COOH in which Ea represents an electroattracting atom or group, at least partly salified by one organic or mineral cation, and b) a polar aprotic solvent; and ii) exposing the reaction medium to the action of micro-waves. This method is used for forming in particular sulphinic or fluorine-containing sulphonic acids.

L'invention concerne un procédé pour greffer un groupement difluorométhyle substitué sur un composé comportant au moins une fonction électrophile, comprenant les étapes consistant à: i) mettre ledit composé comportant au moins une fonction électrophile en présence d'un réactif nucléophile comprenant: a) un acide fluorocarboxylique de formule Ea - CF2 - COOH où Ea représente un atome ou un groupe électroattracteur, au moins partiellement salifié par un cation organique ou minéral, et b) un solvant aprotique polaire; et ii) exposer le milieu réactionnel à l'action de micro-ondes. Ce procédé permet notamment de former des acides sulfiniques ou sulfoniques fluorés.

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